上海市社科联 2026 学术合作项目

                                                               科学食膳 赋能健康

                                      第三届“饮食营养与健康专家论坛暨营养与疾病防治”学术会议

                                          皮肤病食药物质非药物干预酶解活性促反应的综合探讨

                                    皮肤病食药物质非药物干预酶解活性促反应的综合探讨

                                                    桔康(上海)生命科学中心 戴建波

【摘要】慢性皮肤病发病多与炎症失衡、免疫紊乱、皮肤屏障受损、代谢异常密切相关。传统诊疗以药物外用、内服为主，而食药物质非药物干预，依托药食同源原料，借助酶解工艺释放小分子活性物质，成为皮肤病辅助调理的新兴路径。本文综合探讨食药物质酶解活性促反应机理、作用靶点、应用边界、现实局限，为皮肤病膳食营养非药物干预提供理论参考。

【关键词】皮肤病 食药物质干预 酶解活性促反应

【论述研讨】湿疹、皮炎、荨麻疹、痤疮等常见皮肤病，除外界诱因外，肠道、皮肤轴、慢性低度炎症、

氧化应激是重要内在驱动因素。现代营养学与中医药食同源理论交叉，提出膳食营养可调节全身免疫状态，间接改善皮肤微环境。普通食药物质大分子，人体吸收利用率有限；酶解促反应技术，利用生物酶定向水解大分子，生成多肽、寡肽、多酚衍生物等高活性小分子，提升生物利用度，实现非药物营养干预。

1. 大分子降解促活性释放，药食同源食材经复合酶定向酶解，把蛋白、多糖大分子分解为小分子肽、寡糖，释放被包裹的多酚、黄酮活性基团，提升溶解性与体内吸收效率。

2. 抗氧化‑ 抗炎链式反应，酶解生成活性肽清除自由基，抑制皮肤氧化应激，下调促炎因子，减轻全身慢性炎症，通过“肠、皮轴”减少炎症介质向皮肤转运，缓解皮肤红痒、敏感状态。

3. 免疫调节反应，酶解活性组分调节肠道黏膜免疫，改善肠道屏障，减少过敏原、毒素入血，降低异常免疫应答，对过敏性、炎症类皮肤病起到辅助调理。

4. 屏障修复协同作用，部分酶解代谢产物参与脂质代谢，辅助皮肤角质层脂质合成，改善皮肤屏障脆弱。

【总结】食药物质经酶解促反应得到小分子活性组分，通过抗氧化、抗炎、调节肠、皮轴免疫，在慢性皮肤病稳定期具备可观的非药物辅助干预潜力。但现阶段依旧存在循证证据不足、工艺标准化有待完善等痛点。未来需要更多标准化研究，建立皮肤病分型对应的食药物质酶解干预范式，推动“科学膳食赋能皮肤健康”产业规范化发展。

                                                 地址：上海食文化研究会会议室   会议时间：2026 年 9 月 17 日

Shanghai Social Science Federation 2026 Academic Cooperation Project

Scientific diet empowers health

The 3rd "Diet, Nutrition and Health Expert Forum and Nutrition and Disease Prevention and

66Control" Academic Conference

Comprehensive discussion on the non-drug intervention of enzymatic activity to promote the

reaction of enzymatic activity in skin disease food

Jiekang (Shanghai) Life Science Centre Dai Jianbo

【Abstract】The incidence of chronic skin diseases is mostly closely related to inflammatoryimbalance, immune disorders, skin barrier damage and metabolic abnormalities. Traditional diagnosisand treatment is mainly based on external and internal use of drugs, while the substance of food isnon-drug intervention. Relying on the raw materials of the same origin of medicine and food, therelease of small molecule active substances with the help of enzymatic process, it has become anemerging path for auxiliary conditioning of dermatology. This paper comprehensively discusses thereaction mechanism, target of action, application boundary and practical limitations of enzymatic

activity in food and pharmaceutical substances, and provides theoretical reference for non-drugntervention in dietary nutrition for skin diseases.

【Keyword】Dermatology, food and drug substance intervention, enzymatic activity to promote thereaction

【Discussion】Eczema, dermatitis, urticaria, acne and other common skin diseases, in addition to external triggers,

intestines, skin axis, chronic low-grade inflammation, and oxidative stress are important internaldriving factors. The intersection of modern nutrition and the theory of homologous food intraditional Chinese medicine, it is proposed that dietary nutrition can regulate the immune status ofthe whole body and indirectly improve the skin microenvironment. The absorption and utilisation rate of large molecules of ordinary food substances is limited by the human body; enzymatic reaction technology uses bioenzymes to directionally hydrolyse macromolecules to produce highly active small molecules such as polypeptides, oligopeptides and polyphenol derivatives, improve bioavailability and

realise non-drug nutrition intervention.

1. Macromolecule degradation promotes active release. Medicinal and food homologeneous ingredients are enzymatically decomposed by complex enzyme, decompose protein and polysaccharide macromolecules into small molecular peptides and oligosaccharides, and release the wrapped polyphenols and flavonoid active groups to improve solubility and in vivo absorption efficiency.

2. Anti-oxidant-anti-inflammatory chain reaction, enzymatic to produce active peptides to remove free radicals, inhibit skin oxidative stress, down-regate pro-inflammatory factors, reduce systemic chronic inflammation, reduce the transportation of inflammatory mediators to the skin through the "intestine and skin axis", and relieve the redness, itching and sensitivity of the skin.

3. Immunomodulatory response, enzymatic active components regulate intestinal mucosal immunity,improve intestinal barrier, reduce allergens and toxins into the blood, reduce abnormal immune response, and play an auxiliary role in conditioning for allergic and inflammatory skin diseases.

4. With the synergistic effect of barrier repair, some enzymatic metabolites participate in lipid metabolism, assist the lipid synthesis of the cuticle layer of the skin, and improve the vulnerability of the skin barrier.

【Summary】The active components of small molecules are obtained by enzymatic reaction. Through antioxidant, anti-inflammatory, and regulation of intestinal and skin axis immunity, it has considerable potential for non-drug-assisted intervention in the stable period of chronic skin diseases. However, at this stage, there are still pain points such as insufficient evidence-based evidence and process standardisation to be improved. In the future, more standardised research is needed to establish a dietary enzymatic intervention paradigm corresponding to the type of skin diseases, and to promote the standardised development of the "scientific diet empowers skin health" industry.

Address: Conference Room of Shanghai Food Culture Research Association Meeting

Time: September 17, 2026

审撰 ：食药物质 健康中国栏目组  愚晏

摄影 ：冯赟超  陈金宝

翻译 ：国际食药物质与健康产业联盟 执行秘书长  孙丽

校对：国际疾病非药物干预科学应用联盟（中国代表处）执行秘书长 吴玲