14】报告题目：药食同源食药物质应用改善老龄群体骨质退化的临床研究 

                                                 第二届食药物质健康中国国际高峰论坛 

                                                 暨"菩惠宁"癌瘤非药物干预产品功效认证新闻发布会 

                                                        同济大学附属东方医院 

                                                                     吴玉宽 

摘要：老龄群体骨质退化以骨量减少、骨微结构破坏、骨脆性增加为核心特征，属中医“骨痿”“骨痹” 范畴，核心病机为肝肾亏虚、脾肾不足、血瘀络阻。药食同源食药物质兼具补益功效与食用安全性，契合 老龄群体长期非药物干预需求。

关键词：食药物质 补益肝肾、健脾养血临床 

论述：基于中医“肾主骨”理论，结合现代临床研究，系统探讨药食同源食药物质改善老龄骨质退化的作用机制、临床疗效、配伍应用及安全性，为老龄骨质疏松的食药物质非药物干预提供科学依据与实践方案。 现状分析： 

（一）老龄骨质退化现状 

我国 60 岁以上老年人骨质疏松患病率达 36%，女性高达 49%，骨质退化引发的骨折、骨痛、活动受限，严 重影响老龄人生存质量，增加医疗负担。目前西医干预以钙剂+维生素 D 为主，辅以双膦酸盐、雌激素等 药物，存在吸收差、副作用大、长期依从性低等问题。 

（二）药食同源非药物干预优势 

中医“药食同源、食疗为先”理念，强调“肾主骨生髓、脾主运化养骨”，老龄骨质退化核心是肝肾精亏、 气血不足。药食同源食药物质，性味平和、补益肝肾、健脾养血、安全无毒，适合老龄群体长期食用，可 多靶点调节骨代谢、提升骨密度、改善骨质量，弥补西药干预短板。 

（三）研究核心目的 

系统评价药食同源食药物质单味及复方干预老龄骨质退化的临床疗效，解析其“补肾-健脾-活血”协同作用机制，优化食疗配伍方案，为开发安全、有效、便捷的老龄护骨功能性食品提供临床支撑。临床疗效：临 床对照研究显示，食药物质产品非药物干预 12 个月，老龄骨质疏松患者腰椎骨密度提升 5.8%、股骨颈骨密度提升 4.9%，骨痛、腰膝酸软改善率达 89%，显著优于单纯钙剂组（提升 2.1%），且无肝肾功能损伤、 胃肠道不适等不良反应。 

（四）安全性评价 

药食同源食药物质长期食用安全、耐受性好，临床研究显示： 

• 单味及复方干预 6-12 个月，老龄患者肝肾功能、血常规、尿常规均无异常； 

• 少数患者初期可能出现轻微腹胀、口干，调整剂量或饭后食用后可缓解，无严重不良反应； 

• 符合《药食同源物品目录》标准，无毒性成分、无药物依赖风险，适合老龄群体长期食用。 

总结：药食同源食药物质改善老龄骨质退化，理论契合、疗效确切、安全无毒、依从性好。单味物质可多 靶点调节骨代谢、提升骨密度、改善骨质量；复方配伍遵循“补肾-健脾-活血”协同原则，疗效优于单味， 且辨证施膳可精准适配不同证型老龄患者。未来需强化高质量临床研究、机制解析、剂型创新、标准建设， 推动药食同源食药物质在老龄骨质疏松干预中的广泛应用，为老龄群体骨骼健康提供安全、有效、可持续 的药食同源疾病非药物方案，助力健康老龄化。 

14】Report topic:Clinical research on the improvement of bone degeneration in ageing groups by the application of 

medicinal food homology 

The 2nd China International Summit Forum on Food and Drug Quality Health 

Press conference on efficacy certification of "Puhuining" cancer tumour non-drug intervention products 

Oriental Hospital Affiliated to Tongji University 

Yukuan Wu 

Abstract：Bone degeneration in the ageing group is characterised by reduced bone mass, bone microstructure  destruction and increased bone brittleness as the core. It belongs to the category of "bone impotence" and "bone  paralysis" in traditional Chinese medicine. The core pathogenic mechanism is liver and kidney deficiency, spleen andkidney deficiency, and blood stasis obstruction. The medicinal substance of the same origin of medicinal food has both  tonic effect and edible safety, which meets the long-term non-drug intervention needs of the ageing group. 

Keyword：Food and medicinal substance Tonic and benefit the liver and kidney, strengthen the spleen and nourish  the blood clinical 

Expound：Based on the theory of "kidney main bone" in traditional Chinese medicine, combined with modern clinical  research, we systematically explore the mechanism, clinical efficacy, matching application and safety of drug quality of  medicinal food homology to improve bone degeneration in ageing, and provide a scientific basis and practical plan for  non-drug intervention of food quality in ageing osteoporosis. 

Analysis of the current situation： 

（一）Current situation of bone degeneration in ageing 

The prevalence of osteoporosis among the elderly over 60 years old in China has reached 36%, and the prevalence of  women is as high as 49%. Fracture, bone pain and limited movement caused by bone degeneration seriously affect the  quality of survival of the elderly and increase the medical burden. At present, Western medicine intervention is mainly  calcium + vitamin D, supplemented by diphosphonate, oestrogen and other drugs, which has problems such as poor  absorption, large side effects and low long-term compliance. 

（二）Advantages of non-drug intervention of the same origin of medicine and food 

The concept of "medicine and food are of the same origin, food treatment is the first" of traditional Chinese medicine  emphasises that "the kidney is the main bone marrow, and the spleen is the main transport and nourishes the bone". 

The core of bone degeneration in old age is the liver and kidney essence deficiency and qi and blood deficiency. The  medicinal food is of the same origin. It is peaceful in taste, beneficial to the liver and kidney, strengthens the spleen  and nourishes the blood, and is safe and non-toxic. It is suitable for long-term consumption by the elderly. It can  regulate bone metabolism in multiple targets, improve bone density, improve bone quality, and make up for the  shortcomings of Western medicine intervention. 

（三）The core purpose of the research  Systematically evaluate the clinical effect of drug quality single flavour and compound intervention in ageing bone  degeneration of medicinal food homology, analyse its synergistic mechanism of "kidney-strengthening spleen-active  blood", optimise the food therapy matching scheme, and provide clinical support for the development of safe, 

effective and convenient bone-protecting functional food for ageing. Clinical efficacy: Clinical control studies show  that after 12 months of non-drug intervention of drug-drug products, the lumbar bone density of elderly osteoporosis  patients increased by 5.8%, the femoral neck bone density increased by 4.9%, and the improvement rate of bone pain  and lumbar and knee tenderness reached 89%, which was significantly better than the simple calcium group (upprosed  by 2.1%), and there was no liver and kidney. Adverse reactions such as functional damage and gastrointestinal  discomfort. 

（四）Safety evaluation 

It is safe and tolerable for long-term consumption of medicinal food of the same origin. Clinical research shows that: 

• After 6-12 months of single-flavoured and compound intervention, there is no abnormality in liver and kidney  function, blood routine and urine routine of elderly patients; 

• A small number of patients may have mild bloating and dry mouth in the early stage, which can be relieved after  adjusting the dose or eating after meals, and there are no serious adverse reactions; 

• It meets the standard of the Catalogue of Items of the Same Origin of Medicine and Food, has no toxic ingredients and no risk of drug dependence, and is suitable for long-term  consumption by the elderly. 

Conclusion：The medicinal food of the same origin of the medicine improves the bone degeneration of ageing. The theory fits, the therapeutic effect is accurate, safe and non-toxic, and the compliance is good. Single-flavoured  substances can regulate bone metabolism at multiple targets, improve bone density, and improve bone quality; the  compound combination follows the principle of "toning kidney-strengthening the spleen-invigorating blood", which  has a better therapeutic effect than single flavour, and the identification of diet can be accurately adapted to elderly  patients with different syndromes. In the future, it is necessary to strengthen high-quality clinical research, mechanism  analysis, dosage form innovation and standard construction, promote the wide application of medicinal food homology  drug quality in the intervention of osteoporosis in the elderly, provide safe, effective and sustainable non-drug  solutions for the bone health of the elderly, and help healthy ageing.

编辑：食药物质国际交流栏目组  愚晏

翻译：国际食药物质与健康产业联盟 执行秘书长 孙丽

校对：国际疾病非药物干预科学应用联盟（中国代表处）执行秘书长 吴玲