16】报告题目：皮肤病数据科学分析药食同源产品临床应用研究

                                                                      第二届食药物质健康中国国际高峰论坛

                                                          暨"菩惠宁"癌瘤非药物干预产品功效认证新闻发布会

                                                                        上海云殿信息科技有限公司 技术总监

                                                                                                 戴建波

基于真实世界数据与机器学习的疗效评价与模式识别

摘   要：慢性皮肤病并非单纯的体表病变，而是长期系统性消耗性疾病，其核心特征表现为慢性迁延、反复

发作、治疗耐受性差，构成了显著的公共卫生负担

关键词：药食同源应用于皮肤病治疗核心优势，在于其“安全、作用温和持久、整体调理”，弥补了现行

西医治疗“长期用药安全性不足、停药易复发”的结构性短板。

论   述：

疾病负担与未满足的临床需要

1.慢性皮肤病的"灾害"在于其慢性侵蚀性：它将患者的尊严、耐心与财富一点点磨碎。

2. 特应性皮炎 (AD)：瘙痒-搔抓的恶性循环导致睡眠碎片化，长期外用激素引发"用也不是，停也不是"的

治疗悖论。

3. 银屑病 (PsO)：好发于青壮年，不仅是皮损，更常伴发代谢综合征与关节损害，导致严重的社会心理打

击。

4. 痤疮与玫瑰痤疮：炎症后遗症（瘢痕、红斑）具有不可逆性，精准打击患者心理健康。

核心对比：外用糖皮质激素长期使用会导致皮肤萎缩、毛细血管扩张、屏障进一步受损；系统免疫抑制剂

（如环孢素、甲氨蝶呤）存在肝肾毒性与感染风险。患者长期使用激素后，皮肤受体下调，一旦停药即出

现剧烈反跳（红肿、渗液加剧）。

药食同源优势：列入国家卫健委目录的物质（如茯苓、山药、百合、金银花等）经过长期食用历史验证，

无明显的器官毒性，适合用于慢性病维持期的长期管理。药食同源产品（尤其是健脾利湿、清热解毒类）

可通过修复屏障、调节免疫稳态，帮助患者平稳度过激素减量期，实现“症状逐步稳定”

尽管药食同源产品因其"天然、安全"的属性受到青睐，但在皮肤病领域的临床应用仍面临严峻挑战：

资料与方法

数据预处理

本研究构建了多模态数据库，数据预处理遵循以下流程：

术语标准化映射表

针对皮肤科专科术语建立映射表

结   果：

本节将展示数据清洗后的分布情况、临床疗效评估结果以及大数据洞察。

1 基线特征与数据质量：患者年龄、性别、病程、基线严重程度等分布

2 临床疗效评估用：交互项或分层切割

3 大数据洞察：对皮损向量做 K-means / hierarchical clustering（比如用：红斑%/渗出%/苔藓化%/瘙痒 VAS/

病程 五个维度），看能分出几簇

讨   论：本研究通过整合真实世界数据与机器学习技术，系统评估了药食同源产品在皮肤病管理中的应用价

值。

主要发现：药食同源干预在改善慢性苔藓化皮损的主观瘙痒方面表现突出，且能显著减少外用激素的依赖

剂量。然而，在急性渗出期，其单用效果有限，仍需联合短期抗炎治疗。

局限性：本研究为回顾性设计，存在固有的选择偏倚和信息偏倚。未来需要开展前瞻性随机对照试验（RCT）

进一步验证本研究发现的具体亚型人体的疗效差异。

16】Report topic:Scientific analysis of skin disease data and clinical application research of medicinal food homology

products

The 2nd China International Summit Forum on Food and Drug Quality Health

Press conference on efficacy certification of "Puhuining" cancer tumour non-drug intervention products

Shanghai Yundian Information Technology Co., Ltd. Technical Director

Jianbo Dai

Effectiveness evaluation and pattern recognition based on real-world data and machine learning

Abstract：Chronic skin diseases are not simple surface lesions, but long-term systemic wasting diseases. Its core

characteristics are chronic delay, repeated attacks, and poor treatment tolerance, which constitutes a significant public

health burden.

Keyword：The core advantage of the application of medicinal food and food in the treatment of skin diseases lies in its

"safety, mild and lasting effect, and overall conditioning", which makes up for the structural shortcomings of the

current Western medicine treatment of "insufficient safety of long-term use and easy recurrence of drug suspension".

Disease burden and unmet clinical needs

1.The "disaster" of chronic skin disease lies in its chronic erosion: it grinds the patient's dignity, patience and wealth

little by little.

2.Atopic dermatitis (AD): The vicious circle of itching and scratching leads to fragmentation of sleep, and long-term

external use of hormones causes the treatment paradox of "not to use, and it is not good to stop".

3.Psoriasis (PsO): It is easy to develop in young and middle age. It is not only skin damage, but also often accompanied

by metabolic syndrome and joint damage, leading to serious social and psychological shocks.

4.Acne and rose acne: The sequelae of inflammation (scars, erythema) are irreversible and accurately affect the mental

health of patients.

Core comparison: Long-term use of external glucocorticoids will lead to skin atrophy, capillary dilatation, and further

damage to the barrier; systemic immunosuppressants (such as cyclosporine and methotrexate) have the risk of liver and

renal toxicity and infection. After the patient uses hormones for a long time, the skin receptor is down-regulated. Once

the drug is stopped, there will be a violent rebound (redness and swelling, exudation is aggravated).

Advantages of the same origin of medicinal food: Substances listed in the catalogue of the National Health

Commission (such as poria, yam, lily, honeysuckle, etc.) have been verified for long-term consumption history and

have no obvious organ toxicity, which is suitable for long-term management of chronic disease maintenance. Products

of the same origin of medicinal food (especially those that strengthen the spleen and moisture, clear heat and detoxify)

can help patients get through the hormone reduction period smoothly and achieve "soft landing" by repairing the

barrier and regulating the immune homeosity.

Although medicinal and food products of the same origin are favoured because of their "natural and safe" properties,

their clinical applications in the field of skin diseases still face serious challenges:

Methods

Data preprocessing

This study builds a multi-modal database, and the data preprocessing follows the following process:

Terminology Standardisation Mapping Table

Establish a mapping table for specialised terms in dermatology

Results

This section will show the distribution after data cleaning, clinical efficacy evaluation results and big data insights.

1 Baseline characteristics and data quality: patient's age, gender, course of disease, baseline severity, etc.

2 For clinical efficacy evaluation: interactive items or layered cutting

3 Big data insight: do K-means / hierarchical clustering on the skin damage vector (for example:

erythema%/exudation%/mossification%/itching VAS/progic course five dimensions) to see how many clusters can

be divided

Discuss：By integrating real-world data and machine learning technology, this study systematically evaluates the

application value of medicinal food homology products in the management of skin diseases.

The main discovery：Medicinal-food homologenic intervention is outstanding in improving the subjective itching of

chronic mossy skin lesions, and can significantly reduce the dependent dose of external hormones. However, in the

acute exudation period, its effect alone is limited, and it still needs to be combined with short-term anti-inflammatory

treatment.

Limitations: This study is a retrospective design, and there are inherent selection bias and information bias. In the

future, it is necessary to carry out a prospective randomised controlled trial (RCT) to further verify the difference in

therapeutic effect of specific subtypes of human bodies found in this study.

编辑：食药物质国际交流栏目组  愚晏

翻译：国际食药物质与健康产业联盟 执行秘书长 孙丽

校对：国际疾病非药物干预科学应用联盟（中国代表处）执行秘书长 吴玲