上海市社科联 2026 学术合作项目

                                                                 科学食膳 赋能健康

                                      第三届“饮食营养与健康专家论坛暨营养与疾病防治”学术会议

                                                恶性淋巴瘤的营养辅助治疗研究与干预探讨

                                                          上海长海医院 血液内科 董群生

【摘要】恶性淋巴瘤属于高代谢、高消耗性血液系统恶性肿瘤，肿瘤异常增殖引发机体系统性炎症反应与代谢重编程，叠加放化疗对消化道屏障与免疫体系的损伤，患者营养不良、肌肉衰减、免疫抑制发生率显著高于普通实体肿瘤，直接降低抗肿瘤治疗耐受性、延长住院周期、影响远期预后。科学营养辅助治疗是淋巴瘤综合规范化诊疗的重要组成部分，可通过纠正代谢紊乱、调控肿瘤微环境、修复机体免疫屏障实现增效减毒。本文结合临床血液肿瘤诊疗实践，深入探讨恶性淋巴瘤全程化营养干预的病理机制、应用价值与现存短板，提出个体化、分层化、周期化的膳食营养干预思路。研究证实，全程精准营养支持能够有效改善患者躯体代谢状态，降低并发症发生率，是实现“营养赋能疾病防治”的关键路径。

【关键词】恶性淋巴瘤 营养辅助治疗 代谢重编程 放化疗 膳食干预 疾病防治

【论述研讨】恶性淋巴瘤发病进程中存在显著的肿瘤代谢重编程现象，机体由正常能量代谢转向无氧糖酵

解为主的异常代谢模式，持续消耗骨骼肌与内脏蛋白，诱发慢性消耗性营养不良与低度炎症稳态。化疗、靶向及免疫治疗虽可抑制肿瘤增殖，但会进一步损伤胃肠道黏膜屏障、抑制骨髓造血功能，引发厌食、吸收障碍、肠道菌群紊乱，形成“肿瘤消耗+医源性损伤”的双重代谢失衡，严重影响治疗连续性。精准营养辅助治疗可靶向干预淋巴瘤患者的病理代谢机制。通过优化优质蛋白、支链氨基酸、不饱和脂肪酸及抗氧化营养素配比，可有效抑制机体过度炎症反应、延缓肌肉衰减、修复肠道屏障功能，提升机体对放化疗、免疫治疗的耐受度。同时，科学膳食干预可改善机体免疫细胞活性，重塑抗肿瘤免疫微环境，降低免疫治疗相关不良反应发生率，实现营养支持与临床治疗的协同增益。

当前临床仍存在明显短板：

一、淋巴瘤营养干预多为通用模式，缺乏基于肿瘤分型、治疗阶段、体质指数及炎症指标的分层干预方案。

二、临床重抗肿瘤治疗、轻代谢营养管理，全程营养筛查与动态评估体系缺失。

三、患者普遍存在过度忌口、盲目滋补等饮食误区，加剧代谢紊乱，制约临床疗效提升。

【总结】 恶性淋巴瘤的疾病管理不再局限于单一药物治疗，代谢调控与营养修复已成为肿瘤全程规范化管理的核心环节。依托科学膳食赋能疾病防治，实施分阶段、个体化、动态化的营养辅助干预，能够有效纠正肿瘤性代谢紊乱、减轻治疗毒副损伤、稳固机体免疫功能、改善患者远期生存质量。在大健康与精准营养理念下，临床应构建“筛查—评估—干预—随访”闭环营养管理体系，推动肿瘤治疗与营养干预深度融合，以科学膳食助力恶性淋巴瘤精细化、规范化的全程疾病防控。

                                          地址：上海食文化研究会会议室会议               时间：2026 年 9 月 17 日

Shanghai Social Science Federation 2026 Academic Cooperation Project

Scientific diet empowers health

The 3rd "Diet, Nutrition and Health Expert Forum and Nutrition and Disease Prevention and

Control" Academic Conference

Research and intervention on nutritionally assisted treatment of malignant lymphoma

Department of Haematology, Shanghai Changhai Hospital Dong Qunsheng

【Abstract】Malignant lymphoma is a malignant tumour of the high-metabolism and high-consumption blood system. Abnormal tumour proliferation causes the body's systemi inflammatory reaction and metabolic reprogramming, and the damage of radiotherapy to the digestive barrier and immune system. The incidence of malnutrition, muscle attenuation and immunosuppression in patients is significantly higher than that of ordinary solid tumours, directly

Reduce the tolerance of antitumour treatment, prolong the hospitalisation cycle, and affect the long-term prognosis. Scientific nutrition-assisted treatment is an important part of the comprehensiveand standardised diagnosis and  treatment of lymphoma. It can achieve efficacy and toxicity reductionby correcting metabolic disorders, regulating the  tumour microenvironment, and repairing the body's immune barrier. In combination with the clinical practice of haematological tumour diagnosis and treatment, this paper deeply explores the pathological mechanism, application value and existingshortcomings of the whole-process nutritional intervention of malignant lymphoma, and puts forward the idea of individualised, layered and periodic dietary nutrition intervention. Research confirms that

accurate nutritional support throughout the whole process can effectively improve the metabolicstatus of patients and  reduce the incidence of complications, which is the key path to realise"nutrition-enabled disease prevention and control".

【Keyword】Malignant lymphoma, nutritional assisted treatment, metabolic reprogramming, radiotherapy and chemotherapy, dietary intervention, disease prevention and control

【Discussion】In the pathogenesis of malignant lymphoma, there is a significant phenomenon of tumour metabolism reprogramming. The body changes from normal energy metabolism to abnormal metabolic mode based on anaerobic glycolysis, which continues to consume skeletal muscle and visceral protein, and induces chronic consumptive malnutrition and low-grade inflammatoryhomeostasis. Although chemotherapy, targeted and immunotherapy can  inhibit tumour proliferation, they will further damage the gastrointestinal mucosal barrier, inhibit bone marrow haematopoietic function, cause anorexia, absorption disorder, intestinal flora disorder, and form a double metabolic

imbalance of "tumour consumption + iatrogenic injury", which seriously affects the continuity oftreatment. Precise nutrition-assisted treatment can target the pathological metabolic mechanism of lymphoma patients. By optimising the ratio of high-quality protein, branched-chain amino acids, unsaturated fattyacids and antioxidant nutrients, it can  effectively inhibit the body's excessive inflammatory reaction, delay muscle decay, repair intestinal barrier function, and improve the body's tolerance to radiationchemotherapy and immunotherapy. At the same time, scientific dietary  intervention can improve the activity of the body's immune cells, reshape the anti-tumour immune microenvironment, reduce the incidence of adverse reactions related to immunotherapy, and achieve the synergy of nutritional

support and clinical treatment. At present, there are still obvious shortcomings in clinical practice: first, lymphoma nutrition intervention is mostly a general model, and there is a lack of layered intervention plan based on tumour type, treatment stage, body mass index and inflammatory indicators; second, clinical anti-tumour treatment, light metabolic nutrition management, and the whole-process nutritionscreening and dynamic evaluation system are missing; third, the  patient There are widespread dietary misunderstandings such as excessive taboo and blind nourishment, which aggravate metabolic disorders and restrict the improvement of clinical efficacy.

【Summary】The disease management of malignant lymphoma is no longer limited to a single drugtreatment, and  metabolic regulation and nutritional repair have become the core links of the standardised management of tumours throughout the whole process. Relying on scientific diet to empower disease prevention and control, the implementation of phased, individualised and dynamic nutritional auxiliary intervention can effectively correct tumour metabolism disorders, reducetreatment toxic side damage, stabilise the body's immune function, and improve the long- term quality of life of patients. Under the concept of big health and precise nutrition, clinical practice should build

a closed-loop nutrition management system of "screening-assessment-intervention-follow-up", promote the deep integration of tumour treatment and nutritional intervention, and help the whole process of disease prevention and control of malignant lymphoma refined and standardised with scientific diet.

Address: Conference Room of Shanghai Food Culture Research Association Meeting

Time: September 17, 2026

审撰 ：食药物质 健康中国栏目组  愚晏

摄影 ：冯赟超  陈金宝

翻译 ：国际食药物质与健康产业联盟 执行秘书长  孙丽

校对：国际疾病非药物干预科学应用联盟（中国代表处）执行秘书长 吴玲