7】报告题目：慢性病食药物质非药物干预研究

                                                           第二届食药物质健康中国国际高峰论坛

                                                 暨"菩惠宁"癌瘤非药物干预产品功效认证新闻发布会

                                                 中国营养与医疗健康有限公司（香港） 董事长 赖平星

摘要：慢性病具有病程长、易反复、难根治的特点，长期药物治疗存在副作用累积、依从性差、治标不治本等问题

关键词：食药物质天然功能性资源 调节代谢 干预慢性病进展

论述：近年来，生活方式改变促使高血压、高血脂、糖尿病、肥胖及胃肠疾病等慢性病高发且日趋年轻化。

慢性病具有病程长、易反复、难根治的特点，长期药物治疗存在副作用累积、依从性差、治标不治本等问题。食药物质作为药食同源的天然功能性资源，安全性高、适宜长期摄入，能够通过调节代谢、改善免疫、修复机体微生态、缓解慢性低度损伤等多重途径干预慢性病进展。以食药物质为核心，结合膳食优化、运动调理、肠道干预与健康管理的非药物干预模式，符合慢性病“预防为先、长期养护、稳态调控”的防治理念。慢性病多由长期饮食失衡、久坐少动、作息紊乱、精神压力过大等不良因素累积引发，以代谢紊乱、免疫失衡、慢性低度炎症、脏腑功能减退为主要病理特征。现阶段临床治疗多依赖化学药物控制指标，虽可短期控制症状，但无法彻底纠正机体失衡状态，长期服药易造成肝肾负担、肠道损伤及免疫功能下降，难以满足全民健康预防与长期康养需求。慢性病的本质是机体长期处于代谢紊乱与慢性损伤状态，并非单一器官病变，而是全身稳态失衡的综合表现。长期高糖高脂饮食会引发糖脂代谢异常，久坐不动会降低机体代谢效率、加重脂质堆积，熬夜与焦虑会扰乱内分泌与免疫功能，持续诱发低度损伤，最终发展为器质性慢性病。

讨论：当前慢性病临床治疗存在显著局限：

一是、药物仅能对症控标，无法改善慢病发生的内在体质失衡

二是、长期服用化学合成药物副作用累积，降低患者生活质量三是慢性病需要终身管控，单纯药物模式成本高、患者依从性差因此，构建安全、可持续、可实际化应用的疾病非药物干预体系，是突破慢病防控瓶颈的关键，目前食药物质非药物干预研究和临床应用仍存在短板，基础机制研究较多，大样本长期临床循证证据不足，多数食药物质缺乏统一的干预剂量、周期和适用标准，复方配伍协同机制尚不清晰，精准化、个体化干预方案欠缺。市场应用产品同质化严重，标准化、规范化程度较低，制约了广泛应用与临床推广。

总结：总体而言，食药物质慢性病非药物干预，是通过修复代谢、平衡免疫、清除氧化损伤、稳定自体微生态环境，实现长效控病与体质改善，有效预防和延缓病征发展。随着国际疾病非药物干预科学应用联盟2025 年在法国巴黎成立，有望在慢性病非药物干预机制深化研究、临床证据完善与干预方案标准化，食药物质疾病非药物干预将成为全球慢性病三级预防体系的重要组成部分，可为世界各国慢病患者提供安全、绿色、可持续的新型慢性病非药物干预应用方案。

7】Report topic:Research on non-drug intervention of chronic disease drugs

The 2nd China International Summit Forum on Food and Drug Quality Health

Press conference on efficacy certification of "Puhuining" cancer tumour non-drug intervention products

China Nutrition and Medical Health Co., Ltd. (Hong Kong) Chairman

Pingxing Lai

Abstract：Chronic diseases have the characteristics of long course, easy recurrence, and difficult to cure. Long-term

drug treatment has problems such as accumulation of side effects, poor compliance, and treating the symptoms

without treating the root cause.

Keyword：Natural functional resources of food and medicinal substances Regulate metabolism Intervention in the

progression of chronic diseases

Expound：In recent years, lifestyle changes have led to the high incidence and youth of chronic diseases such as

hypertension, hyperlipidaemia, diabetes, obesity and gastrointestinal diseases. Chronic diseases have the characteristics

of long course of disease, easy recurrence, and difficult to cure. Long-term drug treatment has problems such as

accumulation of side effects, poor compliance, and treating symptoms but not treating the root cause. As a natural

functional resource of the same origin of medicine and food, it is safe and suitable for long-term intake. It canintervene in the progression of chronic diseases through multiple ways such as regulating metabolism, improving

immunity, repairing the body's microecology, and alleviating chronic low-degree injuries.Taking dietary drug quality as

the core, combined with dietary optimisation, exercise conditioning, intestinal intervention and health management

non-drug intervention mode, it is in line with the prevention and control concept of "prevention first, long-term

maintenance, steady-state regulation" for chronic diseases. Chronic diseases are mostly caused by the accumulation of

adverse factors such as long-term dietary imbalance, sedentary and low movement, routine disorder, and excessive

mental stress. The main pathological characteristics are metabolic disorders, immune imbalance, chronic low-degree

inflammation, and decreased visceral function. At present, clinical treatment mostly relies on chemical drug control

indicators. Although symptoms can be controlled in the short term, it cannot completely correct the imbalance of the

body. Long-term medication is easy to cause liver and kidney burden, intestinal damage and decreased immune

function, which is difficult to meet the needs of national health prevention and long-term health care.The essence of

chronic diseases is that the body is in a state of metabolic disorder and chronic injury for a long time. It is not a single

organ lesion, but a comprehensive manifestation of systemic homeostatic imbalance. Long-term high-sugar and

high-fat diet will cause abnormal glucose-lipid metabolism. Sitting stillness will reduce the body's metabolic efficiency

and aggravate lipid accumulation. Staying up late and anxiety will disturb endocrine and immune function, continue to

induce low-grade damage, and eventually develop into organic chronic diseases.

Discussion：At present, there are significant limitations in the clinical treatment of chronic diseases: first, drugs can only control the standard according to the symptoms, which cannot improve the inherent constitution imbalance of

chronic diseases. Second, the accumulation of side effects of long-term use of chemical synthetic drugs reduces the

quality of life of patients. Third, chronic diseases need to be controlled for life. The cost of simple drugs is high and

the patient' compliance is poor. Therefore, the composition Building a safe, sustainable and practical non-drug

intervention system for diseases is the key to breaking through the bottleneck of chronic disease prevention and

control. At present, there are still shortcomings in the research and clinical application of non-drug intervention in diet.

There are many basic mechanism studies, and the long-term clinical evidence-based evidence of large samples is

insufficient. Most food and drug quality lacks a unified intervention dose. , cycle and applicable standards, the coordination mechanism of compound matching is not yet clear, and there is a lack of accurate and individualised

intervention plans. The homogenisation of market application products is serious, and the degree of standardisation

and normalisation is low, which restricts the extensive application and clinical promotion.

Conclusion：In general, non-drug intervention for chronic diseases of food and medicine can effectively prevent and delay the development of symptoms by repairing metabolism, balancing immunity, removing oxidative damage, and stabilising the autologous micro-ecological environment. With the establishment of the International Alliance for Disease Non-Drug Intervention Science and Application in Paris, France in 2025, it is expected to deepen research on non-drug intervention mechanisms for chronic diseases, improve clinical evidence and standardise intervention programs. Non-drug intervention for drug-drug diseases will become an important part of the global third-level prevention system for chronic diseases, which can Patients with chronic diseases in various countries provide safe,green and sustainable non-drug intervention applications for new chronic diseases.

编辑：食药物质国际交流栏目组  愚晏

翻译：国际食药物质与健康产业联盟 执行秘书长 孙丽

校对：国际疾病非药物干预科学应用联盟（中国代表处）执行秘书长 吴玲